Parahydrogen and synthesis allow dramatically enhanced nuclear alignment
نویسندگان
چکیده
منابع مشابه
Parahydrogen-enhanced zero-field nuclear magnetic resonance
Nuclear magnetic resonance, conventionally detected in magnetic fields of several tesla, is a powerful analytical tool for the determination of molecular identity, structure and function. With the advent of prepolarization methods and detection schemes using atomic magnetometers or superconducting quantum interference devices, interest in NMR in fields comparable to the Earth’s magnetic field a...
متن کاملFundamental aspects of parahydrogen enhanced low-field nuclear magnetic resonance.
We report new phenomena in low-field 1H nuclear magnetic resonance (NMR) spectroscopy using parahydrogen induced polarization (PHIP), enabling determination of chemical shift differences, δν, and the scalar coupling constant J. NMR experiments performed with thermal polarization in millitesla magnetic fields do not allow the determination of scalar coupling constants for homonuclear coupled spi...
متن کاملPASADENA hyperpolarization: Instrumentation and preparation of tracers for in vivo application
Motivation In the dawn of hyperpolarization (HP) of molecules in solution for biomedical application, the question of suitable instrumentation is imperative. Dynamic Nuclear Polarization (DNP) polarizers are commercially available, but rather cost-intensive. Nevertheless, DNP is used by an increasing number of laboratories, while Parahydrogen And Synthesis Allow Dramatically Enhanced Nuclear Al...
متن کاملZero-field NMR enhanced by parahydrogen in reversible exchange.
We have recently demonstrated that sensitive and chemically specific NMR spectra can be recorded in the absence of a magnetic field using hydrogenative parahydrogen induced polarization (PHIP) (1-3) and detection with an optical atomic magnetometer. Here, we show that non-hydrogenative parahydrogen-induced polarization (4-6) (NH-PHIP) can also dramatically enhance the sensitivity of zero-fiel...
متن کاملHyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism.
Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization-parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium polarization transfer; Brute Force; (1)H hype...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 1987
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja00252a049